PAPERS
Selected publications from recent years.
A complete publication list can be found on Google Scholar
2025
Single-point mutations in disordered proteins: Linking sequence, ensemble, and function. E Flores, N Acharya, C.A. Castañeda, S Sukenik. Current Opinion in Structural Biology, Volume 91, 102987.
Article
Correlating disordered activation domain ensembles with gene expression levels. E Flores, A.R. Camacho, E Cuevas-Zepeda, M.B. McCoy, F Yu, M.V. Staller, S Sukenik. Biophysical Reports, Volume 5, Issue 1, 100195
Article
LEA_4 motifs function alone and in conjunction with synergistic cosolutes to protect a labile enzyme during desiccation. V Nicholson, K Nguyen, E Gollub, M McCoy, F Yu, A.S. Holehouse, S Sukenik, T.C. Boothby. Protein Science. 2025; 34(2):e70028
Article
2024
Protein surface chemistry encodes an adaptive tolerance to desiccation. P.S. Romero-Pérez, H.M. Moran, A Horani, A Truong, E Manriquez-Sandoval, J.F Ramirez, A Martinez, E Gollub, K Hunter, et al.
Preprint
Disordered proteins interact with the chemical environment to tune their protective function during drying. KC Shraddha, K.H. Nguyen, V Nicholson, A Walgren, T Trent, E Gollub, P.S. Romero-Perez, A.S. Holehouse, S Sukenik, T.C. Boothby. eLife 13:RP97231
Article
Measuring the effects of infection on viral disordered proteins. PS Koenig, S Sukenik. Biophysical Journal 123 (3), 214a
Article
YAP condensates are highly organized hubs. S Hao, Y.J. Lee, N.B. Goldfajn, E Flores, et al. iScience, Volume 27, Issue 6, 109927
Article
Structural biases in disordered proteins are prevalent in the cell. D Moses, K Guadalupe, F Yu, E Flores, A Perez, R McAnelly, N M Shamoon, E Cuevas-Zepeda, A Merg, E W. Martin, A S. Holehouse, S Sukenik. Nat Struct Mol Biol 31, 283–292 (2024).
Helicity of a tardigrade disordered protein contributes to its protective function during desiccation. S Biswas, E Gollub, F Yu, G Ginell, A Holehouse, S Sukenik, et al. Protein Science. 2024; 33(2):e4872.
Article
Labile assembly of a tardigrade protein induces biostasis. S Sanchez-Martinez... F Yu, E Gollub... S Sukenik... TC Boothby. Protein Science. 2024; 33(4):e4941
2023
Intrinsically disordered regions are poised to act as sensors of cellular chemistry. David Moses, Garrett M. Ginell, Alex S. Holehouse, Shahar Sukenik
Review (Trends Biochem. Sci)
Helicity of a tardigrade disordered protein promotes desiccation tolerance. Sourav Biswas, Edith Gollub, Feng Yu, Garrett Ginell, Shahar Sukenik, Thomas C. Boothby
When Phased Without Water: Biophysics of Cellular Desiccation, from Biomolecules to Condensates. Paulette Sofia Romero-Perez, Yanniv Dorone, Eduardo Flores, Shahar Sukenik, Steven Boeynaems
Structural preferences shape the entropic force of disordered protein ensembles. Feng Yu, Shahar Sukenik
2022
YAP condensates are highly organized hubs for YAP/TEAD transcription. Siyuan Hao, Hannah Fuehrer, Eduardo Flores, Justin Demmerle, Jennifer Lippincott-Schwartz, Zhe Liu, Shahar Sukenik, Danfeng Kai
2021
Hidden structure in disordered proteins is adaptive to intracellular changes. D Moses, K Guadalupe, F Yu, E Flores, A Perez, R McAnelly, N M Shamoon, E Cuevas-Zepeda, A Merg, E W. Martin, A S. Holehouse, S Sukenik
Article (Preprint)
​
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells. Cuevas-Velazquez, C.L., Vellosillo, T., Guadalupe, K. et al.
Article (Nat Commun)
​
Article (Molecular Biology of the Cell)
​
Computational modelling of protein conformational changes-application to the opening SARS-CoV-2 spike. A Kucherova, S Strango, S Sukenik, M Theillard
Article (Journal of Computational Physics)
​
A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation, Y Dorone, S Boeynaems,
E Flores,...S Sukenik, A D Gitler, S Y Rhee
Article (Cell)
​
2020
Probing the Hidden Sensitivity of Intrinsically Disordered Proteins to their Chemical Environment
D Moses, F Yu, G Ginell, N M Shamoon, P S Koenig, A S Holehouse, S Sukenik
Article (J. Phys. Chem. Lett.)
​
Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells
C L Cuevas-Velazquez, ..., S Sukenik, J R Dinneny
​
Controlling Structural Bias in Intrinsically Disordered Proteins Using Solution Space Scanning. A S Holehouse, S Sukenik
Article (J. Chem. Theor. Comput.)
